GMP Certificated 99% Purity Sirolimus Rapamycin 53123-88-9

• CAS No.: 53123-88-9
• Formula: C51h79no13
• EINECS: 262-640-9
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: shengbang
• Colour: Yellow
• Purity: >99%
• Suitable for: Elderly, Children, Adult
• Density: 1.2±0.1 g/cm3
• Boiling Point: 973.0±75.0 °c at 760 Mmhg
• Melting Point: 183-185°c
• Transport Package: Capacity 25kg/Drum
• Specification: Carton loading
• Trademark: SHENGBANG
• Origin: China
• HS Code: 2942000000
• Production Capacity: 2000 Ton/Year

Product Description

Product Description

Product Name	Raw Pharmaceutical Grade Material Sirolimus  CAS 53123-88-9 Powder Rapamycin
CAS	53123-88-9
Appearance	White Crystalline Powder
Molecular formula	C51H79NO13
Molecular Weight	914.18
Assay	98%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

 

Application

Rapamycin is a triene macrolide antibiotic,which demonstrates anti-fungal,anti-inflammatory,anti-tumor and immunosuppressive
properties.

Rapamycin has been shown to block T-cell activation and proliferation,as well as,the activation of p70 S6 kinase and exhibits strong
binding to FK506 binding proteins. 

Rapamycin also inhibits the activity of the protein,mTOR(mammalian target of rapamycin) which functions in a signaling pathway to
promote tumor growth.

Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction
of mTOR with target proteins in this signaling pathway.

 

Rapamycin (RAPA) is a novel macrolide immunosuppressant is now often used as a transplanted organ to maintain immunity drugs
(especially kidney transplants), to mitigate the immune organ rejection after transplant surgery, but scientists it recently found another
purpose: for the treatment of Alzheimer's disease (senile dementia).

Target of rapamycin (mTOR) as an intracellular kinases pathway abnormalities can induce a variety of diseases. As rapamycin mTOR
inhibitor targeting, to treat with this pathway is closely related to tumors, including renal cell carcinoma, lymphoma, lung cancer,
liver cancer, breast cancer, neuroendocrine carcinoma and gastric cancer

 

 

What is Rapamycin?

 

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. 

Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases,which have PI 4-kinase and autophosphorylating activities.

The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity,but does inhibit FRAP autophosphorylation. 

Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. 

Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is
potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. 

Rapamycin is an inhibitor of mTOR.

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Detailed Photos

 

 

Packaging & Shipping

 

Packing and delivering

 

Certifications

 

Certifications

FAQ

Q1: Are you a manufacturer or trading company?
Re: We are one company integrated industry and trade. No matter the products we manufacture or trade, high quality products and competitive price always will be provided for you.

Q2: May I get one sample before placing order?
Re: Yes, we'd like to provide sample for you. free samples(max 1Kg) are available, but freight cost will be born by customers.

Q3: Which payment is available for your company?
Re: In order to prompt our cooperation, there are some payment methods for your choice. T/T(USD), Western union, Paypal, Credit card, Alipay or Alibaba trade insurance all is ok. You can choose the one which is convenient for you.

Q4: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, T/T, EMS, etc.) or by air. Usually it will cost 2-5 days that you can get the goods after delivery.
For large quantity products, shipment is better. It will cost days to weeks to come to your destination port, which depends on where the port is.

Q5: Is there any possible to use my appointed label or package?
Re: Sure. If needed, we'd like to use label or package according to your requirement.

Q6: How can you guarantee the goods you offer is qualified?
Re: We always believe honesty and responsibility are basis of one company, so whatever products we provide for you all are high qualified. If the goods can't come to the quality we promise, you can ask for refund.