Hot Selling Pharmaceutical Grade Brigatinib Cancer Treatment CAS 1197953-54-0 Ap26113 with High Purity

• Customization: Available
• Powder: Yes
• Customized: Non-Customized
• Model NO.: CAS 1197953-54-0
• Certification: GMP, ISO 9001
• Suitable for: Elderly, Children, Adult
• State: Powder
• Purity: >99%
• Sample: Available
• Density: 1.31±0.1 g/cm3
• Shelf Life: 2 Years
• Test Method: HPLC
• Transport Package: Aluminum Foil Bag/Cartons/Foil Bags
• Specification: 99%
• Trademark: Haiwei
• Origin: China
• HS Code: 29335990
• Production Capacity: 5000kg/Month

Product Description

Product Description

Product Name: Brigatinib
Synonyms: Brigatinib;AP26113 (Brigatinib);Brigatinib, AP26113;5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine;5-chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine;brigatib;140455;Bogtinib (AP26113)
CAS: 1197953-54-0
MF: C29H39ClN7O2P
MW: 584.092421
EINECS: 621-260-7

Melting point: 96-97°C
Boiling point: 781.8±70.0 °C
Density: 1.31±0.1 g/cm3
Storage temp.: Store at RT
Appearance: Off-White Powder

Brigatinib (AP26113) is a medicine used to treat cancer that suppresses  (EGFR) and anaplastic lymphoma kinase (ALK). Brigatinib is a selective agonist against variations of EGFR as opposed to the wild mutant forms. The drug also illustrates selectivity against the ALK-EML4 fusion gene, which is a fundamental aspect of the modification of susceptible lung parenchyma. Brigatinib is prescribed for patients with specific abnormal genes and when the non-small cell lung cancer (NSCLC) is non-responsive to management with other medications. Brigatinib is classified as a kinase inhibitor, whose mechanism of action entails suppressing the action of abnormal proteins that enhance the multiplication of cancer cells.

Detailed Photos

Application

Brigatinib, also known as AP-26113, is an orally active, potent and selective Dual ALK/EGFR inhibitor. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells. In addition, AP26113 appears to overcome mutation-based resistance. ALK belongs to the in sulin receptor superfamily and plays an important role in nervous system development; ALK dysregulation and gene rearrangements are associated with a series of tumors. EGFR is overexpressed in a variety of cancer cell types.

 

Company Profile

Packaging & Shipping

 

FAQ

1.How long is the delivery time? According to the goods and quantity: General products: About 10 days when received the payment
Dangerous Products: About 15 days when received the payment.
2. What is terms of payment? Normally we can accept TT, LC, DP
3. What kind of trade terms are acceptable? Shipping method: FOB, CFR, CIF
4. May I get one sample before placing order? Yes, we'd like to provide sample for you. For those normal products, you just need to pay the freight; When we have cooperated for a long time or you are our VIP customer, free sample will be offered.
5. How about the Quality Control? We have our own experienced QC and can provide all the certificates and samples for testing. There will be strict inspection and testing for every procedure before shipping. 6. Are you a manufacturer or trading company? We are one company integrated industry and trade. No matter the products we manufacture or trade, high quality products and competitive price always will be provided for you