99% Purity 100% Resend Policy Lab Synthesis Bulk Supply CAS 137862-53-4

• CAS No.: 137862-53-4
• Formula: C24h29n5o3
• EINECS: Na
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: shengbang
• Colour: White
• Purity: >99%
• Suitable for: Elderly, Children, Adult
• Name: Valsartan
• Density: 1.2±0.1 g/cm3
• Boiling Point: 684.9±65.0 °c at 760 Mmhg
• Melting Point: 116-117°c
• Molecular Formula: C24h29n5o3
• Molecular Weight: 435.519
• Flash Point: 368.0±34.3 °c
• Exact Mass: 435.227051
• Psa: 112.07000
• Vapour Pressure: 0.0±2.2 Mmhg at 25°c
• Index of Refraction: 1.587
• Storage Condition: -20°c Freezer, Under Inert Atmos
• Transport Package: Capacity 25kg/Drum
• Specification: Carton loading
• Trademark: SHENGBANG
• Origin: China
• HS Code: 2933990090
• Production Capacity: 2000 Ton/Year

Product Description

Product Description

Product name	Factory Supply Sacubitril Valsar 1038924-70-7 buy Sacubitril Valsartan
Appearance	White powder
Molecular formula	C48h58n6o8
Keywords	Sacubitril Valsartan ,1038924-70-7 Sacubitril Valsartan,LCZ696
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

Application

LCZ696 a drug developed by Novartis Pharmaceutical of the United States for the treatment of heart failure. Heart failure is a life-threatening disease. The patient's heart cannot pump enough blood to supply the body, and appear the symptoms of dyspnea, fatigue and fluid retention slowly, then gradually increased, significantly affect the quality of life.
LCZ696 is a dual-acting angiotensin-receptor enkephalinase inhibitor that has a unique mechanism that is thought to reduce the strain of failing hearts. LCZ696 can enhance the body's natural defense against heart failure, as well as increase the level of natriuretic peptides and other endogenous vasoactive peptides, and inhibit the renin-angiotensin-aldosterone system (RAAS). LCZ696 has combined with Novartis's Hypertension Medication (Diovan, generic name: valsartan) and the experimental drug AHU-377. AHU377 blocks the mechanism of the two peptides responsible for lowering blood pressure. Diovan improves vasodilatation and stimulates the body to excrete sodium and water.
The safety threshold of cardiovascular drugs is extremely high, and LCZ696 even shows a higher safety than conventional drugs. Previously, Novartis vigorously develop the cardiovascular drug- serelaxi, while because of security issues, both the FDA and the European Union did

 

Function of Vildagliptin 

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.

 

 

What is Sacubitril Valsartan

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.

 

 

Detailed Photos

 

 

Packaging & Shipping

 

Packing and delivering

Certification

FAQ

Q1: Are you a manufacturer or trading company?
Re: We are one company integrated industry and trade. No matter the products we manufacture or trade, high quality products and competitive price always will be provided for you.

Q2: May I get one sample before placing order?
Re: Yes, we'd like to provide sample for you. free samples(max 1Kg) are available, but freight cost will be born by customers.

Q3: Which payment is available for your company?
Re: In order to prompt our cooperation, there are some payment methods for your choice. T/T(USD), Western union, Paypal, Credit card, Alipay or Alibaba trade insurance all is ok. You can choose the one which is convenient for you.

Q4: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, T/T, EMS, etc.) or by air. Usually it will cost 2-5 days that you can get the goods after delivery.
For large quantity products, shipment is better. It will cost days to weeks to come to your destination port, which depends on where the port is.

Q5: Is there any possible to use my appointed label or package?
Re: Sure. If needed, we'd like to use label or package according to your requirement.

Q6: How can you guarantee the goods you offer is qualified?
Re: We always believe honesty and responsibility are basis of one company, so whatever products we provide for you all are high qualified. If the goods can't come to the quality we promise, you can ask for refund.